Differential abundance of CK1a provides selectivity for pharmacological CK1a activators to target WNT-dependent tumors
نویسندگان
چکیده
Molecular Oncology Program, Department of Surgery, Miller School of Medicine, University of Miami, Miami, FL 33136, USA. StemSynergy Therapeutics Inc., Miami, FL 33136, USA. Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. Department of Public Health Sciences, Miller School of Medicine, University of Miami, Miami, FL 33136, USA. Sylvester Comprehensive Cancer Center, Miller School of Medicine, University of Miami, Miami, FL 33136, USA. Department of Pathology and Laboratory Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136, USA. Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Division of Gastroenterology, Department of Medicine, Miller School of Medicine, University of Miami, Miami, FL 33136, USA. *Corresponding author. Email: [email protected]
منابع مشابه
Differential abundance of CK1α provides selectivity for pharmacological CK1α activators to target WNT-dependent tumors.
Constitutive WNT activity drives the growth of various human tumors, including nearly all colorectal cancers (CRCs). Despite this prominence in cancer, no WNT inhibitor is currently approved for use in the clinic largely due to the small number of druggable signaling components in the WNT pathway and the substantial toxicity to normal gastrointestinal tissue. We have shown that pyrvinium, which...
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